This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]
APP Knockout 293T Cell Line 
NCBI Gene ID
WB; IHC; IF; Functional Assay
>95% viability before freezing. All cells were tested and found to be free of mycoplasma, bacterial, viruses, and other toxins.
1 vial of knockout cell line
Parental Cell Line
Store at -80 centigrade upon receiving. Liquid nitrogen for a long-term storage. Minimizing freeze- thaw cycles.