Gene Symbol
FH
NCBI Gene ID
2271
Application
WB; IHC; IF; Functional Assay
Other Names
MCL
FMRD
LRCC
HLRCC
MCUL1
1×10^6 cells/vial
Gene Description

The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy. [provided by RefSeq, Jul 2008]

Pathway & Cancer
Renal cell carcinoma
Quality control
>95% viability before freezing. All cells were tested and found to be free of mycoplasma, bacterial, viruses, and other toxins.
Storage
Store at -80 centigrade upon receiving. Liquid nitrogen for a long-term storage. Minimizing freeze- thaw cycles.
Parental Cell Line
293T
Components
1 vial of knockout cell line