Gene Symbol
MAP2K2
NCBI Gene ID
5605
Application
WB; IHC; IF; Functional Assay
Other Names
CFC4
MEK2
MKK2
MAPKK2
PRKMK2
1×10^6 cells/vial
USD
Gene Description

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]

Quality control
>95% viability before freezing. All cells were tested and found to be free of mycoplasma, bacterial, viruses, and other toxins.
Components
1 vial of knockout cell line
Parental Cell Line
293T
Pathway & Cancer
Glioma
Thyroid cancer
Acute myeloid leukemia
Chronic myeloid leukemia
Melanoma
Renal cell carcinoma
Bladder cancer
Endometrial cancer
Prostate cancer
Breast cancer
Non-small cell lung cancer
Rap1
FoxO
Ras
MAPK
INSULIN
cGMP-PKG
Apoptosis
cAMP
mTOR
B cell receptor
T cell receptor
PI3K-Akt
Toll-like receptor
VEGF
ErbB
Storage
Store at -80 centigrade upon receiving. Liquid nitrogen for a long-term storage. Minimizing freeze- thaw cycles.